Simvastatin Review: Best solution for hypercholesterolemia

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Published: 26th January 2011
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Hypercholesterolemia is a major disorder affecting up to 5% of world population and one need to read Simvastatin review to find solutions to this problem. The drug is one of the most commonly prescribed treatments for this condition. Hypercholesterolemia, or excess of cholesterol in blood, is mainly caused by the intake of foods that are high in fat content. The condition is worsened by lack of exercise and a sedentary lifestyle. Some people have also shown this problem because of a genetic condition though there is no final scientific research on this.

Simvastatin has been found effective in alleviating this situation by interacting with the receptors that produce cholesterol. The drug contains statins, which are actively used as a treatment for hypercholesterolemia. Statins interact with the body metabolism and inhibit the functions of 3-hydroxy-3-methylglutaryl coenzyme A HMG-CoA reductase, which contributes to cholesterol production. This lipid-regulating mechanism can reduce cholesterol if one takes the drug on a regular basis.

The mechanism of action of statins is not fully understood but their role in inhibiting the activities of cholesterol producing mechanism. Body metabolism works in such a manner that it is quick to store fat in case the brain sends such signal. It is therefore necessary to counter this problem right at its roots by inhibiting the receptors. The drug is from a family of hypolipidemic compounds and derives its basic formula from a synthetic derivate of Aspergillus terreus. Low density lipoprotein, or LDL, is the bad cholesterol that causes a number of diseases. This drug has been found to cut its percentage by up to 50% in some cases. It has also been identified as effective in cutting down the levels of triglycerides.

The drug is strictly used as a prescription medicine and should not be taken as an over the counter medication. It is used in a specific daily intake dose or as per the indications of a doctor. The minimal amount is available in the format of 5 mg tablets and the maximum is available in the packaging of 80 mg. Doctors usually prescribe the drug after taking into account the overall conditions of a person. They usually prescribe higher quantities in case LDL has risen to alarmingly high levels. They may also prescribe the drug as part of a cocktail therapy.

Major side effects of the drug include allergies in people who have a history of hypersensitive reactions to medicines. Simvastatin review generally lists indigestion as a major side effect that has been observed in up to 10% of users. There are otherwise no major side effects of this medication.

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